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Accutane information sheet. Consumer medicine information



 

Monkeypox is a contagious disease that causes a rash. A board-certified dermatologist explains what the rash looks like and when to seek medical care. This contagious skin disease will usually clear on its own, but sometimes dermatologists recommend treating it. Find out when. Everyone's at risk for skin cancer. These dermatologists' tips tell you how to protect your skin. Find out what may be causing the itch and what can bring relief. If you have what feels like razor bumps or acne on the back of your neck or scalp, you may have acne keloidalis nuchae.

Find out what can help. You can expect permanent results in all but one area. Do you know which one? If you want to diminish a noticeable scar, know these 10 things before having laser treatment. Use these professionally produced online infographics, posters, and videos to help others find and prevent skin cancer. Free to everyone, these materials teach young people about common skin conditions, which can prevent misunderstanding and bullying.

A dermatologist is a medical doctor who specializes in treating the skin, hair, and nails. Dermatologists care for people of all ages. The AADA is advocating to find a solution to help patients get the isotretinoin they need. Patients can help us by sharing their stories. Acne can decrease self-confidence and may cause you to avoid social situations. Isotretinoin eye-soh-tret-in-OH-in is a prescription medication for severe acne.

This type of acne causes deep, painful cysts and nodules, which can be the size of a pencil eraser or larger. As this acne clears, scars often appear. Severe acne can be difficult to treat.

When other treatments fail to clear the skin, isotretinoin may be an option. Treatment with isotretinoin often results in prolonged clearance of acne, which can be permanent for some patients. This is a brand of isotretinoin that is no longer available.

Warning: When you buy this medication from an online site that does not require a prescription, you put your health at serious risk. One course of treatment takes about four to five months.

Sometimes, one course of treatment takes less time or a bit more time. Dermatologists tailor the treatment to each patient. Your safety is a dermatologist's first concern. Due to possible side effects, your dermatologist will talk with you about the risks and benefits of isotretinoin and about your health. This will help your dermatologist decide whether this medication is an option for you. If it is, your dermatologist will share educational materials with you. This can help you decide if you want to take isotretinoin.

The U. This program also helps your dermatologist monitor you while taking isotretinoin. A prescription is good for a day supply of isotretinoin.

To get another prescription, you must:. See your dermatologist every 30 days for follow-up visit, either in-person or by telemedicine. All of these precautions mean that you will be under close medical supervision while taking isotretinoin.

Academy position statement on isotretinoin. Is it really acne? Acne or rosacea? Adult acne Baby acne Stubborn acne Acne symptoms What is acne. Having trouble getting your acne medication? Share your story.

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- Isotretinoin: Overview



    Use in pregnancy Category X : Roaccutane must not be used by females who are pregnant or who may possibly become pregnant while undergoing treatment. Roaccutane is used for more severe cases. Reporting suspected adverse reactions after registration of the medicinal product is important. Effects on laboratory tests. The dose levels, duration of treatment and total cumulative dose in these patients generally far exceeded those recommended for the treatment of acne. Do this even if there are no signs of discomfort or poisoning.

Treatment with isotretinoin often results in prolonged clearance of acne, which can be permanent for some patients. This is a brand of isotretinoin that is no longer available. Warning: When you buy this medication from an online site that does not require a prescription, you put your health at serious risk. One course of treatment takes about four to five months. Sometimes, one course of treatment takes less time or a bit more time. Dermatologists tailor the treatment to each patient.

Your safety is a dermatologist's first concern. Due to possible side effects, your dermatologist will talk with you about the risks and benefits of isotretinoin and about your health. This will help your dermatologist decide whether this medication is an option for you.

Must have a pregnancy test every month during treatment, and a negative test a month after treatment. Must use two 2 different forms of birth control at all times unless agrees not to have sex starting one 1 month before treatment continuing during treatment, and for one 1 month after treatment.

Must agree to see their health care provider every month during treatment for a health check and to get a new prescription. In: T. Fujii and G. Tokyo: Teikyo University Press, pp. Adams J and Lammer EJ. Neurobehavioral teratology of isotretinoin. Reprod Toxicol. Adams J. Similarities in genetic mental retardation and neuroteratogenic syndromes. Pharmacol Biochem Behav. Autret-Leca E et al. Drug safety : an international journal of medical toxicology and drug experience.

Chelliah P and Glass D. Comprehensive review of reports of menstrual irregularities associated with isotretinoin. Choi EJ, Kim N et al. The rates of major malformations after gestational exposure to isotretinoin; a systemic review and meta- analysis. Obstet Gynecol Sci Mar Coleman, R and MacDonald D.

Effects of isotretinoin on male reproductive system. Your doctor will tell you how many Roaccutane capsules to take each day. The dose will be calculated to suit your individual needs and your body weight.

This dose may be adjusted during treatment when your doctor knows how you respond to Roaccutane. Female patients should wait until the 2nd or 3rd day of the next normal menstrual period before starting Roaccutane treatment.

This helps ensure that you aren't pregnant before you start taking Roaccutane. Acne treatment with Roaccutane will usually last 4 to 8 months.

In the first few weeks of treatment your acne may get a little worse before it gets better. Do not worry about this, it is a sign that Roaccutane is working. At the end of this time your acne should have cleared up significantly. Most patients notice their skin condition continues to improve even after Roaccutane treatment is finished. Please note that Roaccutane cannot improve scars or pitting that were present before treatment started, but it will help prevent such skin damage in the future.

Do not try to make up for missed doses by taking an extra dose. This may increase the chance of getting an unwanted side effect. If it is almost time for your next dose, skip the dose you missed and take the next dose when you are meant to. Immediately telephone your doctor or Poisons Information Centre telephone 13 11 26 for advice, or go to Accident and Emergency at your nearest hospital, if you think you or anyone else may have taken too much Roaccutane.

Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Signs of overdose include transient headache; vomiting; facial flushing; reddened, cracked lips; stomach pain; headache; dizziness and unsteady walking.

If you become pregnant while taking Roaccutane, stop taking it and tell your doctor immediately. Roaccutane can cause birth defects damage to unborn babies. You must use strict birth control, starting at least 1 month before you begin taking Roaccutane, for the whole time you are taking Roaccutane and for 1 month after you finish taking Roaccutane. Tell all doctors, dentists and pharmacists who are treating you that you are taking Roaccutane. Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed.

Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily. Be sure to keep all of your appointments with your doctor so that your progress can be checked. Your doctor may ask you to have regular blood tests to monitor your liver function, blood sugar levels and blood cholesterol levels.

If you are intending to do a lot of heavy lifting or exercise, tell your doctor. Your muscles and joints may be more prone to tenderness or stiffness if you do a lot of heavy exercise while taking Roaccutane.

Do not donate blood during treatment with Roaccutane or for at least 1 month after stopping treatment. Be careful driving or operating machinery until you know how Roaccutane affects you. Normally Roaccutane would not affect your ability to drive a car or operate machinery. However, altered night vision and other visual disturbances may occur when taking Roaccutane. Make sure you know how you react to Roaccutane before you drive a car, operate machinery or do anything else that may be dangerous if your vision is affected.

Wearing contact lenses during treatment with Roaccutane may cause discomfort. Roaccutane may cause dry eyes. An eye lubricant or artificial tears, available from your pharmacist, should relieve this problem. Otherwise, you may temporarily need to wear your lenses for shorter periods or wear glasses instead. Avoid excessive sun exposure and solariums and apply sunscreen whilst taking Roaccutane. Your skin may be more prone to sunburn while on Roaccutane. Avoid waxing and dermabrasion whilst taking Roaccutane and for 5 to 6 months after stopping Roaccutane treatment.

Your skin may be more sensitive while on Roaccutane. Waxing may cause dermatitis and dermabrasion may cause scarring during and for several months after Roaccutane treatment.

Your skin and hair may be more delicate during treatment and for a while after Roaccutane treatment. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects. These side effects are usually mild and dose related. Most of them disappear completely in a few days to a few weeks after the dose of Roaccutane is lowered or stopped.

These may be serious side effects. Serious side effects are rare. This is not a complete list of all possible side effects. Others may occur in some people and there may be some side effects not yet known. Tell your doctor if you notice anything else that is making you feel unwell, even if it is not on this list. Keep your capsules in the blister pack until it is time to take them. If you take the capsules out of the packaging they will not keep as well.

Do not leave it in the car or on window sills. Heat and dampness can destroy some medicines. Keep Roaccutane where young children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. If your doctor tells you to stop taking Roaccutane, or the capsules have passed their expiry date, ask your pharmacist what to do with any capsules that are left over.

Roaccutane 20 mg capsule is soft, oval, half brown-red and half opaque white in colour and has "ROA 20" printed on it. Each Roaccutane 20 mg capsule contains isotretinoin 20 mg. Excipients with known effect. Contains soya bean oil refined, hydrogenated and partially hydrogenated.

For the full list of excipients, see Section 6. Roaccutane is indicated for the treatment of severe cystic acne, and a single course of therapy has been shown to result in complete and prolonged remission of disease in many patients. If a second course of therapy is needed, it should not be initiated until at least eight weeks after completion of the first course, since experience has shown that patients may continue to improve while off drug.

Because of significant adverse effects associated with its use, Roaccutane should be reserved for patients with severe cystic acne who are unresponsive to conventional therapy, including systemic antibiotics. The therapeutic response to Roaccutane is dose related and varies between patients. This necessitates individual adjustment of dosage according to the response of the condition and the patient's tolerance of the drug.

In most cases complete or near complete suppression of acne is achieved with a 16 week course of treatment. All patients initially should receive Roaccutane at doses up to 0. It should be noted that transient exacerbation of acne is occasionally seen during this initial period. Satisfactory initial responses have been reported from 0. Relapse rates on the lower doses are higher a second course may be required in about two-thirds of patients on 0.

The daily dosage should be taken with food in the nearest number of whole capsules, either as a single dose or in two divided doses during the day, whichever is more convenient. The above daily dosages of Roaccutane should be continued for 16 weeks to complete the course of treatment. Civil aviation licence holders, including Air Traffic Controllers, have an obligation under section 27 C of the Civil Aviation Act to ground self and report to CAA in case of any change in medical condition that may affect flight safety.

CAA considers the use of isotretinoin to be a change in medical condition. Isotretinoin interacts with a few medications such as some antibiotics and vitamin A products.

Check with your doctor or pharmacist before taking any other medicine or supplements. Looking for Where to get medical help A health professional or service Patient portals Newsletters View all. Acne treatment Belongs to a group of medicines known as retinoids. Your doctor will order certain lab tests to check your response to isotretinoin. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.

You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. Generic alternatives may be available. Isotretinoin pronounced as eye soe tret' i noyn. Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose?

What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names. For all patients: Isotretinoin must not be taken by patients who are pregnant or who may become pregnant. Do not donate blood while you are taking isotretinoin and for 1 month after your treatment. Talk to your doctor about the risks of taking isotretinoin. For female patients: If you can become pregnant, you will need to meet certain requirements during your treatment with isotretinoin.

For male patients: A very small amount of isotretinoin will probably be present in your semen when you take prescribed doses of this medication. Other uses for this medicine. What special precautions should I follow? Before taking isotretinoin, tell your doctor and pharmacist if you are allergic to isotretinoin, vitamin A, any other medications, or any of the ingredients in isotretinoin capsules.

Ask your pharmacist or check the Medication Guide for a list of the inactive ingredients. Be sure to mention medications for seizures such as phenytoin Dilantin ; medications for mental illness; oral steroids such as dexamethasone Decadron, Dexone , methylprednisolone Medrol , and prednisone; tetracycline antibiotics such as demeclocycline Declomycin , doxycycline Monodox, Vibramycin, others , minocycline Minocin, Vectrin , oxytetracycline Terramycin , and tetracycline Sumycin, Tetrex, others ; and vitamin A supplements.

Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

This leaflet answers some common questions about Roaccutane. It does not contain all the available information. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Roaccutane against the benefits they expect it will have for you.

Retinoids work by reducing the amount of the oily substance i. There are many different types of medicines used to treat acne. Roaccutane is used for more severe cases. Ask your doctor if you have any questions about why Roaccutane has been prescribed for you. Do not give Roaccutane to children. Roaccutane may be associated with slowing of growth when used in children before puberty.

The use of Roaccutane in children less than 12 years of age is not recommended. If you have not told your doctor about any of the above, tell them before you start taking Roaccutane. Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription, from a pharmacy, supermarket or health food shop.

These medicines may be affected by Roaccutane or may affect how well it works. You may need to take different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you. Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Roaccutane. Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet. Take Roaccutane exactly as your doctor has prescribed.

Your doctor will tell you how many Roaccutane capsules to take each day. The dose will be calculated to suit your individual needs and your body weight.

This dose may be adjusted during treatment when your doctor knows how you respond to Roaccutane. Female patients should wait until the 2nd or 3rd day of the next normal menstrual period before starting Roaccutane treatment.

This helps ensure that you aren't pregnant before you start taking Roaccutane. Acne treatment with Roaccutane will usually last 4 to 8 months. In the first few weeks of treatment your acne may get a little worse before it gets better. Do not worry about this, it is a sign that Roaccutane is working.

At the end of this time your acne should have cleared up significantly. Most patients notice their skin condition continues to improve even after Roaccutane treatment is finished.

Please note that Roaccutane cannot improve scars or pitting that were present before treatment started, but it will help prevent such skin damage in the future.

Do not try to make up for missed doses by taking an extra dose. This may increase the chance of getting an unwanted side effect. If it is almost time for your next dose, skip the dose you missed and take the next dose when you are meant to. Immediately telephone your doctor or Poisons Information Centre telephone 13 11 26 for advice, or go to Accident and Emergency at your nearest hospital, if you think you or anyone else may have taken too much Roaccutane.

Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Signs of overdose include transient headache; vomiting; facial flushing; reddened, cracked lips; stomach pain; headache; dizziness and unsteady walking.

If you become pregnant while taking Roaccutane, stop taking it and tell your doctor immediately. Roaccutane can cause birth defects damage to unborn babies. You must use strict birth control, starting at least 1 month before you begin taking Roaccutane, for the whole time you are taking Roaccutane and for 1 month after you finish taking Roaccutane.

Tell all doctors, dentists and pharmacists who are treating you that you are taking Roaccutane. Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed. Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily. Be sure to keep all of your appointments with your doctor so that your progress can be checked.

Your doctor may ask you to have regular blood tests to monitor your liver function, blood sugar levels and blood cholesterol levels. If you are intending to do a lot of heavy lifting or exercise, tell your doctor. Your muscles and joints may be more prone to tenderness or stiffness if you do a lot of heavy exercise while taking Roaccutane. Do not donate blood during treatment with Roaccutane or for at least 1 month after stopping treatment. Be careful driving or operating machinery until you know how Roaccutane affects you.

Normally Roaccutane would not affect your ability to drive a car or operate machinery. However, altered night vision and other visual disturbances may occur when taking Roaccutane. Make sure you know how you react to Roaccutane before you drive a car, operate machinery or do anything else that may be dangerous if your vision is affected.

Wearing contact lenses during treatment with Roaccutane may cause discomfort. Roaccutane may cause dry eyes. An eye lubricant or artificial tears, available from your pharmacist, should relieve this problem. Otherwise, you may temporarily need to wear your lenses for shorter periods or wear glasses instead. Avoid excessive sun exposure and solariums and apply sunscreen whilst taking Roaccutane.

Your skin may be more prone to sunburn while on Roaccutane. Avoid waxing and dermabrasion whilst taking Roaccutane and for 5 to 6 months after stopping Roaccutane treatment. Your skin may be more sensitive while on Roaccutane. Waxing may cause dermatitis and dermabrasion may cause scarring during and for several months after Roaccutane treatment.

Your skin and hair may be more delicate during treatment and for a while after Roaccutane treatment. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

These side effects are usually mild and dose related. Most of them disappear completely in a few days to a few weeks after the dose of Roaccutane is lowered or stopped.

These may be serious side effects. Serious side effects are rare. This is not a complete list of all possible side effects. Others may occur in some people and there may be some side effects not yet known.

Tell your doctor if you notice anything else that is making you feel unwell, even if it is not on this list. Keep your capsules in the blister pack until it is time to take them. If you take the capsules out of the packaging they will not keep as well.

Do not leave it in the car or on window sills. Heat and dampness can destroy some medicines. Keep Roaccutane where young children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. If your doctor tells you to stop taking Roaccutane, or the capsules have passed their expiry date, ask your pharmacist what to do with any capsules that are left over.

Roaccutane 20 mg capsule is soft, oval, half brown-red and half opaque white in colour and has "ROA 20" printed on it.

Each Roaccutane 20 mg capsule contains isotretinoin 20 mg. Excipients with known effect. Contains soya bean oil refined, hydrogenated and partially hydrogenated.

For the full list of excipients, see Section 6. Roaccutane is indicated for the treatment of severe cystic acne, and a single course of therapy has been shown to result in complete and prolonged remission of disease in many patients. If a second course of therapy is needed, it should not be initiated until at least eight weeks after completion of the first course, since experience has shown that patients may continue to improve while off drug.

Because of significant adverse effects associated with its use, Roaccutane should be reserved for patients with severe cystic acne who are unresponsive to conventional therapy, including systemic antibiotics. The therapeutic response to Roaccutane is dose related and varies between patients. This necessitates individual adjustment of dosage according to the response of the condition and the patient's tolerance of the drug.

In most cases complete or near complete suppression of acne is achieved with a 16 week course of treatment. All patients initially should receive Roaccutane at doses up to 0.

It should be noted that transient exacerbation of acne is occasionally seen during this initial period. Satisfactory initial responses have been reported from 0. Relapse rates on the lower doses are higher a second course may be required in about two-thirds of patients on 0.

The daily dosage should be taken with food in the nearest number of whole capsules, either as a single dose or in two divided doses during the day, whichever is more convenient. The above daily dosages of Roaccutane should be continued for 16 weeks to complete the course of treatment.

After a period of two months off therapy and if warranted by persistent severe cystic acne, a second course of therapy may be initiated. Use in pregnancy Category X : Roaccutane must not be used by females who are pregnant or who may possibly become pregnant while undergoing treatment.

Roaccutane comes in soft capsules containing either 10 mg or 20 mg isotretinoin. The 10 mg capsules are oval, opaque, coloured brown-red and marked ROA The. 1) The Guide to Best Practices for the iPLEDGE Program includes: isotretinoin teratogenic potential, information on pregnancy testing, and the method to. 1) The Guide to Best Practices for the iPLEDGE Program includes: isotretinoin teratogenic potential, information on pregnancy testing, and the method to. Patients not cured by isotretinoin may require topical medications for maintenance, If you lose your lab sheet, just give the office a call. Type of Contraception: Signed Consent: Y N. Previous Accutane Use: Y N. No. of Courses: Last Use:______. History: LMP: Liver Disease: Y N. Capsule shell. No data available. Particular care needs to be taken in patients with a history of depression and all patients should be monitored for signs of depression. Symptoms appeared after 21 days to 6 months therapy with 40 to mg daily. Mood changes, anxiety, depression, or worsening depression, low mood, aggressive tendencies, thoughts or talk of suicide and self-harm.

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. This sheet is about exposure to isotretinoin in pregnancy and while breastfeeding.

This information should not take the place of medical care and advice from your healthcare provider. Isotretinoin is a prescription medication taken by mouth to treat severe cystic acne that has not responded to other treatments. Isotretinoin is a form of Vitamin A. People who are trying to get pregnant should not be taking isotretinoin.

There have been reports of changes in menstrual periods in some people taking isotretinoin. There are no reports of problems getting pregnant while taking isotretinoin. I am taking isotretinoin, but I would like to stop taking it before pregnancy.

How long does it stay in my body? People eliminate medication at different rates. In healthy adults, it takes up to 10 days, on average, for most of the isotretinoin and its by-products to be gone from the body. However, it is recommended that a person wait one month after stopping isotretinoin before trying to get pregnant. Stop taking the medication right away. As soon as possible, call the healthcare provider who prescribed the isotretinoin and the healthcare provider who will be taking care of you during your pregnancy.

Isotretinoin can cause birth defects. Your healthcare team can talk with you about screening tests and ultrasounds that can detect some birth defects. Screening tests and ultrasound cannot tell if a child may have problems with learning or development. Miscarriage can occur in any pregnancy. This is called the background risk. The chance of having a baby with a birth defect applies even if the medication has been taken for a short time.

Most of the infants with birth defects will have small or absent ears and hearing and eyesight problems. Life-threatening heart defects and fluid around the brain are other birth defects that have be seen in some infants. Some will have a small jaw, small head, cleft palate and some will be born with a small or missing thymus gland a gland that makes hormones. Does taking isotretinoin in pregnancy increase the chance of other pregnancy-related problems?

An increased chance for preterm delivery birth before week 37 has been associated with the use of isotretinoin in pregnancy. Does taking isotretinoin in pregnancy affect future behavior or learning for the child? These issues usually do not get noticed at birth, but are discovered in childhood. Other possible long-term effects on exposed children are unknown. Following are some of the requirements:. There have been no studies looking at the use of isotretinoin during breastfeeding.

It is not known what effect, if any, exposure to isotretinoin through the breast milk can have on a nursing infant. Breastfeeding while taking isotretinoin is not recommended. Be sure to talk to your healthcare provider about all your breastfeeding questions. If a male takes isotretinoin, could it affect fertility ability to get partner pregnant or increase the chance of birth defects? Isotretinoin does not appear to affect sperm, and there have been no reports of isotretinoin causing male infertility.

There have been a few reports of erectile dysfunction and ejaculatory failure in males taking isotretinoin. Studies have not been done in males to see if isotretinoin could increase the chance of birth defects. In general, exposures that fathers or sperm donors have are unlikely to increase the risks to a pregnancy. While our name still contains a reference to mothers, we are updating our resources with more inclusive terms. Use of the term mother or maternal refers to a person who is pregnant.

Use of the term father or paternal refers to a person who contributes sperm. Turn recording back on. Help Accessibility Careers.

Search term. Must sign an Informed Consent Form that contains warnings about the risks of using isotretinoin. Must have a pregnancy test every month during treatment, and a negative test a month after treatment. Must use two 2 different forms of birth control at all times unless agrees not to have sex starting one 1 month before treatment continuing during treatment, and for one 1 month after treatment.

Must agree to see their health care provider every month during treatment for a health check and to get a new prescription. In: T. Fujii and G. Tokyo: Teikyo University Press, pp. Adams J and Lammer EJ. Neurobehavioral teratology of isotretinoin. Reprod Toxicol. Adams J. Similarities in genetic mental retardation and neuroteratogenic syndromes. Pharmacol Biochem Behav. Autret-Leca E et al.

Drug safety : an international journal of medical toxicology and drug experience. Chelliah P and Glass D. Comprehensive review of reports of menstrual irregularities associated with isotretinoin. Choi EJ, Kim N et al. The rates of major malformations after gestational exposure to isotretinoin; a systemic review and meta- analysis. Obstet Gynecol Sci Mar Coleman, R and MacDonald D.

Effects of isotretinoin on male reproductive system. Lancet Committee on Drugs, American Academy of Pediatrics. Retinoid therapy for severe dermatological disorders. Pediatrics Dai WS, et al. Safety of pregnancy after discontinuation of isotretinoin. Arch Dermatol Epidemiology of isotretinoin exposure during pregnancy. J Am Acad Dermatol DiGiovanna JJ, et al. Etretinate: persistent serum levels of a potent teratogen.

Clin Res A. Goldsmith LA, et al. American Academy of Dermatology Consensus Conference on the safe and optimal use of isotretinoin: summary and recommendations. Lammer EJ, et al. Risk for major malformation among human fetuses exposed to isotretinoin cis-retinoic acid. Teratology A. Retinoic acid embryopathy. New Engl J Med Lee SM et al.

A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug. Yonsei medical journal. Loureiro KD et al. American journal of medical genetics.

Part A. Mitchell AA. Oral retinoids: What should the prescriber know about their teratogenic hazards among women of child-bearing potential? Drug Saf 7 2 Nulman I.



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UPDATE 2-Roche stops selling acne drug Accutane | Reuters.Patients going weeks without isotretinoin after website overhaul

Looking for: Reports for ISOTRETINOIN  Click here       .   Current Drug Shortage Bulletins. Generic Name A fact sheet summarizing the...